New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds
A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Access
Discipline
- Mathematical & computational biology
- Environmental sciences
- Paleontology
- Archaeology
- Geography, physical
- Limnology
- Geology
- Geosciences, multidisciplinary
- Astronomy & astrophysics
- Ecology
- Crystallography
- Chemistry, organic
- History
- Biodiversity conservation
- Materials science, multidisciplinary
- Geochemistry & geophysics
- Mineralogy
- Engineering, electrical & electronic
- Physics, atomic, molecular & chemical
- Microbiology
- Water resources
- Chemistry, physical
- Engineering, industrial
- Energy & fuels
- Computer science, artificial intelligence
- Ornithology
- Electrochemistry
- Engineering, mechanical
- Geography
- Plant sciences
- Multidisciplinary sciences
- Meteorology & atmospheric sciences
- Engineering, multidisciplinary
- Computer science, theory & methods
- Statistics & probability
- Materials science, characterization & testing
- Chemistry, inorganic & nuclear
- Agronomy
- Parasitology
- Chemistry, analytical
- Zoology
- Anthropology
- Architecture
- Asian studies
- Behavioral sciences
- Biochemistry & molecular biology
- Cell biology
- Clinical neurology
- Communication
- Computer science, software engineering
- Engineering, chemical
- Engineering, environmental
- Entomology
- Genetics & heredity
- Health care sciences & services
- Infectious diseases
- Materials science, coatings & films
- Materials science, composites
- Neuroimaging
- Neurosciences
- Nuclear science & technology
- Oceanography
- Physics, mathematical
- Physics, multidisciplinary
- Physiology
- Psychiatry
- Psychology
- Robotics
- Toxicology
- Agriculture, multidisciplinary