New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Diversity-oriented Synthesis of Spiropyrrolo[1, 2-a]isoquinoline Derivatives via Diastereoselective and Regiodivergent Three-component 1,3-Dipolar Cycloaddition Reactions: In vitro and in vivo Evaluation of the Antidiabetic Activity of Rhodanine Analogues
An efficient diastereoselective route is developed to get access to novel spiropyrrolo[1,2-a]isoquinoline-oxindole skeletons by a one-potthree-component [3 + 2] cycloaddition reaction of (Z)-5-arylidene-1,3-thiazolidine-2,4-diones, isatin derivatives, and 1,2,3,4-tetrahydroisoquinoline (THIQ). ...
DAT-Af-BASE: database for azole resistant Aspergillus fumigatus
The University hospital of Besançon has an extensive collection of A. fumigatus isolated from clinical and environmental samples. Azole resistant strains are part of this collection and have been characterized: evaluation of resistance phenotypes, sequencing of the main gene involved in resistance, ...
Access
Discipline
Structure
Collection
- Bioorganic synthesis
- Aspergillus fumigatus
- PollenChrono
- Données de thèse
- Single-crystal X-ray structures
- Organic synthesis
- Chimie des eaux-basse vallée de l'Ain
- Dynamique des orogènes anciennes
- Microma
- Gaia
- Données de thèse de Jonas Vanardois
- Faults and shear zones
- Complex directed networks
- Données de thèse de Thomas Leydier
- Données de thèse de Charles Henriot
- Phytomanagement-Chrono
- Hydrogène
- CNR Echinococcoses
- Pile à combustible
- Données de thèse de Alexandre Lhosmot
- Star formation
- OMIV
- Équipe SHARPAC
- Road-side counts
- Inorganic synthesis
- DATA-PHM
- Paleoparasitology
- TNOs
- Données de thèse de Paul Breugnot
- Elaboration des matériaux luminescents
- Bacilles à Gram négatif dans l'environnement
- Histoire des catastrophes
- Génomique bactérienne
- AVKs
- Lipid model membranes
- Molecular dynamics
- Neuro group @ FEMTO-ST
- Organometallic complexes with metal-metal bonds
- Piézométrie Chrono-Environnement
