Mathematical & computational biology
Translations : mathematical & computational biology ; biologie computationnelle
Domain : fundamental biology
New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds
A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Googlomics: Inferring hidden causal relations between pathway members using reduced Google matrix of directed biological networks
Signaling pathways represent parts of the global biological network which connects them into a seamless whole through complex direct and indirect (hidden) crosstalk whose structure can change during normal development or in a pathological conditions such as cancer. Advanced methods for ...
Access
Discipline
- Mathematical & computational biology
- Environmental sciences
- Paleontology
- Archaeology
- Geosciences, multidisciplinary
- Geography, physical
- Ecology
- Geology
- Limnology
- Biodiversity conservation
- Crystallography
- Astronomy & astrophysics
- Water resources
- Chemistry, organic
- Meteorology & atmospheric sciences
- Geochemistry & geophysics
- Physics, atomic, molecular & chemical
- Microbiology
- History
- Multidisciplinary sciences
- Chemistry, analytical
- Engineering, electrical & electronic
- Mineralogy
- Cell biology
- Materials science, multidisciplinary
- Spectroscopy
- Plant sciences
- Chemistry, inorganic & nuclear
- Agronomy
- Chemistry, physical
- Computer science, artificial intelligence
- Energy & fuels
- Engineering, industrial
- Geography
- Physics, mathematical
- Biochemistry & molecular biology
- Parasitology
- Electrochemistry
- Computer science, software engineering
- Computer science, information systems
- Engineering, environmental
- Health care sciences & services
- Language & linguistics
- Linguistics
- Marine & freshwater biology
- Ornithology
- Engineering, mechanical
- Forestry
- Economics
- Mycology
- Zoology
- Agriculture, multidisciplinary
- Behavioral sciences
- Humanities, multidisciplinary
- Instruments & instrumentation
- Materials science, characterization & testing
- Oceanography
- Engineering, multidisciplinary
- Infectious diseases
- Oncology
- Computer science, interdisciplinary applications
- Materials science, composites
- Robotics
- Pathology
- Anatomy & morphology
- Statistics & probability
- Computer science, theory & methods
- Entomology
- Cultural studies
- Microscopy
- Remote sensing
- Pharmacology & pharmacy
- Toxicology
- Sociology
- Tropical medicine
- Genetics & heredity
- Materials science, biomaterials
- Urban studies
- Physiology
- Neurosciences
- Polymer science
- Medical informatics
- Medieval & renaissance studies
- Environmental studies
- Surgery
- Biology
- Philosophy
- Engineering, manufacturing
- Physics, condensed matter
- Architecture
- Physics, multidisciplinary
- Anthropology
- Psychiatry
- Psychology
- Psychology, experimental
- Public, environmental & occupational health
- Radiology, nuclear medicine & medical imaging
- Religion
- Reproductive biology
- Soil science
- Telecommunications
- Food science & technology
- Asian studies
- Engineering, civil
- Engineering, chemical
- Education & educational research
- Transportation science & technology
- Imaging science & photographic technology
- Developmental biology
- Law
- Dermatology
- Logic
- Construction & building technology
- Materials science, coatings & films
- Agricultural economics & policy
- Mathematics
- Mathematics, applied
- Mechanics
- Computer science, hardware & architecture
- Communication
- Clinical neurology
- Music
- Chemistry, applied
- Nanoscience & nanotechnology
- Neuroimaging
- Nuclear science & technology
- Acoustics
- Operations research & management science
- Biophysics
- Biology, miscellaneous
