Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Diversity-oriented Synthesis of Spiropyrrolo[1, 2-a]isoquinoline Derivatives via Diastereoselective and Regiodivergent Three-component 1,3-Dipolar Cycloaddition Reactions: In vitro and in vivo Evaluation of the Antidiabetic Activity of Rhodanine Analogues
An efficient diastereoselective route is developed to get access to novel spiropyrrolo[1,2-a]isoquinoline-oxindole skeletons by a one-potthree-component [3 + 2] cycloaddition reaction of (Z)-5-arylidene-1,3-thiazolidine-2,4-diones, isatin derivatives, and 1,2,3,4-tetrahydroisoquinoline (THIQ). ...
Reactivity of CuI and CuBr toward Dialkyl Sulfides RSR: From Discrete Molecular Cu4I4S4 and Cu8I8S6 Clusters to Luminescent Copper(I) Coordination Polymers
The CuX salts (X = I, Br) react with SR2 to form molecular clusters of the types [(R2S)4(Cu4I4)] and [(R2S)6(Cu8I8)] or to give 1D polymers and 2D metal−organic frameworks. The cluster nuclearity and connectivity as well as the dimensionality of these compounds depend on the steric demand of SR2, ...
Access
Discipline
- Materials science, characterization & testing
- Crystallography
- Environmental sciences
- Chemistry, organic
- Archaeology
- Microbiology
- Geosciences, multidisciplinary
- Materials science, multidisciplinary
- Geology
- Chemistry, inorganic & nuclear
- Cell biology
- Engineering, environmental
- Chemistry, physical
- Ecology
- Geography, physical
- Mycology
- Engineering, electrical & electronic
- Forestry
- Mineralogy
- Water resources
- Engineering, mechanical
- Biodiversity conservation
- Engineering, industrial
- History
- Engineering, multidisciplinary
- Computer science, software engineering
- Computer science, artificial intelligence
- Parasitology
- Mathematical & computational biology
- Electrochemistry
- Biochemistry & molecular biology
- Energy & fuels
- Geochemistry & geophysics
- Geography
- Polymer science
- Robotics
- Infectious diseases
- Language & linguistics
- Marine & freshwater biology
- Materials science, biomaterials
- Food science & technology
- Materials science, coatings & films
- Entomology
- Engineering, chemical
- Mechanics
- Medical informatics
- Medieval & renaissance studies
- Agronomy
- Dermatology
- Music
- Computer science, information systems
- Neurosciences
- Ornithology
- Paleontology
- Chemistry, applied
- Pathology
- Physics, atomic, molecular & chemical
- Urban studies
- Psychology, experimental
- Remote sensing
- Behavioral sciences
- Surgery
- Toxicology
- Transportation science & technology
- Health care sciences & services
- Imaging science & photographic technology