Bioorganic synthesis
Creation of collection : 30 Sep 2021
New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Diversity-oriented Synthesis of Spiropyrrolo[1, 2-a]isoquinoline Derivatives via Diastereoselective and Regiodivergent Three-component 1,3-Dipolar Cycloaddition Reactions: In vitro and in vivo Evaluation of the Antidiabetic Activity of Rhodanine Analogues
An efficient diastereoselective route is developed to get access to novel spiropyrrolo[1,2-a]isoquinoline-oxindole skeletons by a one-potthree-component [3 + 2] cycloaddition reaction of (Z)-5-arylidene-1,3-thiazolidine-2,4-diones, isatin derivatives, and 1,2,3,4-tetrahydroisoquinoline (THIQ). ...
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- Bioorganic synthesis
- PollenChrono
- Données de thèse
- Single-crystal X-ray structures
- Organic synthesis
- Calculated spectroscopic databases
- Dynamique des orogènes anciennes
- Microma
- Chimie des eaux-basse vallée de l'Ain
- Gaia
- Données de thèse de Jonas Vanardois
- Complex directed networks
- Faults and shear zones
- Données de thèse de Thomas Leydier
- DATA-PHM
- Données de thèse de Charles Henriot
- Équipe SHARPAC
- Hydrogène
- OMIV
- Phytomanagement-Chrono
- Données de thèse de Alexandre Lhosmot
- CNR Echinococcoses
- Star formation
- Données de thèse de Angélica Leticia Cahuana Velasteguí
- Pile à combustible
- Inorganic synthesis
- Road-side counts
- Aspergillus fumigatus
- Elaboration des matériaux luminescents
- Histoire des catastrophes
- Neuro group @ FEMTO-ST
- TNOs
- Paleoparasitology
- Bacilles à Gram négatif dans l'environnement
- Données de thèse de Paul Breugnot
- Données de thèse de Florian Scalvini
- Batteries
- Organometallic complexes with metal-metal bonds
- Données de thèse de Ouassim Boukhennoufa
- Vieillissement
- Piézométrie Chrono-Environnement
- AVKs
- Données issues de la collaboration entre l'équipe FEMTO-ST/DATA-PHM et le service de médecine nucléaire du CHU de Besançon
- POPSU - Axe 2 : Mesurer les transitions dans les lieux d'habitat
- Lipid model membranes
- Malacologie continentale
- Génomique bactérienne
- Molecular dynamics
- Early Triassic fossils from the western USA Basin
