New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds
A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Natural site: peat bog near the lake's outlet. 16 palynological samples. The selection was made in several drillings. Two pollen tests performed in 2021 towards the lake outlet.
Pollen tests in the filling of a circular depression (ice rest, pockmark?) in the heart of a meander of the Bienne. Two samples: 162 and 200 cm deep.
A reaction of biomass-derived aldehyde synringaldehyde and half an equivalent of 1,4-dichlorobut-2-yne was attempted in order to obtain a bis-aldehyde with an alkyne spacer. The reaction was carried out in a basic media to effect bis O-alkylation, as described in literature for the preparation of ...
4′-(5-Methylfuran-2-yl)-2,2′:6′,2″-terpyridine: A New Ligand Obtained from a Biomass-Derived Aldehyde with Potential Application in Metal-Catalyzed Reactions
The new ligand 4′-(5-methylfuran-2-yl)-2,2′:6′,2″-terpyridine (1) was prepared in one step from 2-acetylpyridine and 5-methylfurfural. The latter is an aldehyde that can be readily obtained from biomass. The new terpyridine molecule was characterized by 1H and 13C-NMR spectroscopy as well as by ...
Diversity-oriented Synthesis of Spiropyrrolo[1, 2-a]isoquinoline Derivatives via Diastereoselective and Regiodivergent Three-component 1,3-Dipolar Cycloaddition Reactions: In vitro and in vivo Evaluation of the Antidiabetic Activity of Rhodanine Analogues
An efficient diastereoselective route is developed to get access to novel spiropyrrolo[1,2-a]isoquinoline-oxindole skeletons by a one-potthree-component [3 + 2] cycloaddition reaction of (Z)-5-arylidene-1,3-thiazolidine-2,4-diones, isatin derivatives, and 1,2,3,4-tetrahydroisoquinoline (THIQ). ...
A new thiophene-substituted terpyridine derivative has been prepared and characterized. This ligand features a thiophene heterocycle (as an electrochemically polymerizable unit) as well as two chlorine atoms for further functionalization.
A new pyrrole-substituted terpyridine derivative that possesses an allene moiety was obtained as an “unexpected” sole product during an attempt to alkylate the N-atom of pyrrole with propargyl bromide in order to obtain an alkyne-functionalized terpyridine.
A new thiophene-substituted terpyridine derivative has been prepared through the reaction between 5-n-propylthiophene-2-carboxaldehyde and 2-acetylpyridine. This terpyridine derivative bears an alkyl chain linked via a thiophene heterocycle.
Natural site over the alignment of the A39 motorway; drilling. Two series: T1 (18 poor samples) and T2 (88 palynological samples + 2 radiocarbon datings). Samples often difficult to read. Publication CRAS, 1996.
Natural site: drilling with motorised "russian" core. 120 palynological samples. + 6 radiocarbon datings. 2015 publication: only the "gallo-roman" part.
Archaeological site: rock shelter. 10 palynological samples. Only one acceptable result. Archaeological excavation: Ch. Cupillard, SRA de Franche-Comté.
Archaeological site. Lake dwelling. 9 palynological samples (related to M. Magny PhD thesis, 1991).
Archaeological site. Lake dwelling. 11 palynological samples.
Archaeological excavation of rural settlement. 7 palynological samples. Approximate geographical coordinates.
Natural site: wooded swamp. 144 palynological samples with 2 radiocarbon datings. Sometimes quite poor. Further analyses were done in the village of Grozon around the salt springs by E. Gauthier (PhD, 2001).
Archaeological site. Lake dwelling. 14 palynological samples + radiocarbon and dendrochronological datings.
Peat bog; 51 palynological samples. Other analyses on this site by Carole Bégeot and Pascale Ruffaldi (2006)
The archaeological surveys carried out on the Le Locle bypass road have made it possible to make several test borring in the upper part of the fill of the area located south of the city, between the city and the Col des Roches, in the Marais des Calame and Marais de la Molière. Two sections were ...
Two boreholes (CID I of 5.77 m and CID II of 7.63 m) were drilled off the Domaine de Chalain (east bank), 65-70 m from the shore. 57 pollen samples were taken from CID I and 21 from CID II + 5 radiocarbon dates.
Only one sample in a natural depression in the heart of the castle excavation.
Peat bog. 9 palynological samples. KTH testing (see : Sjörgen, P. 2007. Mires and Peat, International Mire Conservation Group and International Peat Society ; Gobet, 2014)
Natural site: drilling. 71 palynological samples + 4 radiocarbon datings (one is wrong, too recent). Malacological studies by Nicole Limondin (1997).
- environmental sciences
- geography, physical
- geosciences, multidisciplinary
- chemistry, organic
- mathematical & computational biology
- materials science, characterization & testing
- plant sciences
- geochemistry & geophysics
- chemistry, physical
- medieval & renaissance studies
- multidisciplinary sciences
- Elaboration des composés héterocycliques antidiabétiques et antimicrobiens
- Construction des territoires et des paysages des îles croates de Ces et de Krk
- IATEKA - Interdisciplinary approach to the territorial evolution of the Kvarner archipelago
- PCR 74-Annecy Paléoenvironnement et archéologie de la rive nord du lac d'Annecy
- Thèse de doctorat en chimie - Florian Charrier
- Organic synthesis
- Données de thèse
- Single-crystal X-ray structures
- Dynamique des orogènes anciennes
- Chimie des eaux-basse vallée de l'Ain
- Calculated spectroscopic databases
- Données de thèse de Jonas Vanardois
- Faults and shear zones
- Complex directed networks
- Données de thèse de Thomas Leydier
- Données de thèse de Charles Henriot
- CNR Echinococcoses
- Star formation
- Road-side counts
- Bioorganic synthesis
- Équipe SHERPAC
- Inorganic synthesis
- Bacilles à Gram négatif dans l'environnement
- Elaboration des matériaux luminescents
- Histoire des catastrophes
- Neuro group @ FEMTO-ST
- Pile à combustible
- Piézométrie Chrono-Environnement
- Aspergillus fumigatus
- Molecular dynamics
- Lipid model membranes
- Génomique bactérienne
- Organometallic complexes with metal-metal bonds