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New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies

In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...

Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds

A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical ...

Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors

In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...

Pollen analysis - Les Rousses (F-39), Les Rousses lake

Collected date : from 1986 to 2021
Creators : Hervé Richard

Natural site: peat bog near the lake's outlet. 16 palynological samples. The selection was made in several drillings. Two pollen tests performed in 2021 towards the lake outlet.

Pollen analysis - Vaux-lès-Saint-Claude (F-39), Eau Morte

Collected date : from Oct 2021 ongoing
Creators : Hervé Richard

Pollen tests in the filling of a circular depression (ice rest, pockmark?) in the heart of a meander of the Bienne. Two samples: 162 and 200 cm deep.


Disciplines : chemistry, organic
Collected date : from 2020 to 2021
Creators : Jérôme Husson

A reaction of biomass-derived aldehyde synringaldehyde and half an equivalent of 1,4-dichlorobut-2-yne was attempted in order to obtain a bis-aldehyde with an alkyne spacer. The reaction was carried out in a basic media to effect bis O-alkylation, as described in literature for the preparation of ...

4′-(5-Methylfuran-2-yl)-2,2′:6′,2″-terpyridine: A New Ligand Obtained from a Biomass-Derived Aldehyde with Potential Application in Metal-Catalyzed Reactions

Disciplines : chemistry, organic
Collected date : from 2017 to 2018

The new ligand 4′-(5-methylfuran-2-yl)-2,2′:6′,2″-terpyridine (1) was prepared in one step from 2-acetylpyridine and 5-methylfurfural. The latter is an aldehyde that can be readily obtained from biomass. The new terpyridine molecule was characterized by 1H and 13C-NMR spectroscopy as well as by ...

Diversity-oriented Synthesis of Spiropyrrolo[1, 2-a]isoquinoline Derivatives via Diastereoselective and Regiodivergent Three-component 1,3-Dipolar Cycloaddition Reactions: In vitro and in vivo Evaluation of the Antidiabetic Activity of Rhodanine Analogues

Collected date : from 2018 to 2021

An efficient diastereoselective route is developed to get access to novel spiropyrrolo[1,2-a]isoquinoline-oxindole skeletons by a one-potthree-component [3 + 2] cycloaddition reaction of (Z)-5-arylidene-1,3-thiazolidine-2,4-diones, isatin derivatives, and 1,2,3,4-tetrahydroisoquinoline (THIQ). ...


Disciplines : chemistry, organic
Collected date : from 2017 to 2018

A new thiophene-substituted terpyridine derivative has been prepared and characterized. This ligand features a thiophene heterocycle (as an electrochemically polymerizable unit) as well as two chlorine atoms for further functionalization.


Disciplines : chemistry, organic
Collected date : from 2018 to 2019

A new pyrrole-substituted terpyridine derivative that possesses an allene moiety was obtained as an “unexpected” sole product during an attempt to alkylate the N-atom of pyrrole with propargyl bromide in order to obtain an alkyne-functionalized terpyridine.


Disciplines : chemistry, organic
Collected date : 2020

A new thiophene-substituted terpyridine derivative has been prepared through the reaction between 5-n-propylthiophene-2-carboxaldehyde and 2-acetylpyridine. This terpyridine derivative bears an alkyl chain linked via a thiophene heterocycle.

Pollen analysis - Le Miroir (F-71), La Tuilerie (La Peupleraie), A39-T1 and T2

Collected date : 1995
Creators : Hervé Richard

Natural site over the alignment of the A39 motorway; drilling. Two series: T1 (18 poor samples) and T2 (88 palynological samples + 2 radiocarbon datings). Samples often difficult to read. Publication CRAS, 1996.

Pollen analysis - Auneau (F-28), L'Hermitage (detour road 18/116/19)

Collected date : from 2011 to 2012

Natural site: drilling with motorised "russian" core. 120 palynological samples. + 6 radiocarbon datings. 2015 publication: only the "gallo-roman" part.

Pollen analysis - Villers-le-Lac (F-25), La Roche aux pêcheurs

Collected date : 1992
Creators : Hervé Richard

Archaeological site: rock shelter. 10 palynological samples. Only one acceptable result. Archaeological excavation: Ch. Cupillard, SRA de Franche-Comté.

Pollen analysis - Fontenu (F-39), îlot David-1987, FG 30, 86 S-C, 86 G23

Collected date : 1987
Creators : Hervé Richard

Archaeological site. Lake dwelling. 9 palynological samples (related to M. Magny PhD thesis, 1991).

Pollen analysis - Fontenu (F-39), Lac de Chalain, îlot David, A 33/34

Archaeological site. Lake dwelling. 11 palynological samples.

Pollen analysis - Héricourt (F-70), La Lizaine (chemin de l'usine)

Collected date : 1989
Creators : Hervé Richard

Archaeological excavation of rural settlement. 7 palynological samples. Approximate geographical coordinates.

Pollen analysis - Grozon (F-39), L'étang (Marais)

Collected date : 1981
Creators : Hervé Richard

Natural site: wooded swamp. 144 palynological samples with 2 radiocarbon datings. Sometimes quite poor. Further analyses were done in the village of Grozon around the salt springs by E. Gauthier (PhD, 2001).

Pollen analysis - Clairvaux-les-lacs (F-39), Station II

Collected date : 1983
Creators : Hervé Richard

Archaeological site. Lake dwelling. 14 palynological samples + radiocarbon and dendrochronological datings.

Pollen analysis - Bonlieu (F-39), Le Lautrey (point 205)

Collected date : 1995

Peat bog; 51 palynological samples. Other analyses on this site by Carole Bégeot and Pascale Ruffaldi (2006)

Pollen analysis - Le Locle (NE, CH), Col des Roches (Projet H20)

Collected date : from Jun 2020 ongoing

The archaeological surveys carried out on the Le Locle bypass road have made it possible to make several test borring in the upper part of the fill of the area located south of the city, between the city and the Col des Roches, in the Marais des Calame and Marais de la Molière. Two sections were ...

Pollen analysis - Fontenu (F-39), Domaine CID I et CID II

Collected date : from Mar 2021 ongoing

Two boreholes (CID I of 5.77 m and CID II of 7.63 m) were drilled off the Domaine de Chalain (east bank), 65-70 m from the shore. 57 pollen samples were taken from CID I and 21 from CID II + 5 radiocarbon dates.

Pollen analysis - La Châteleine (F-39), Au vieux château

Collected date : from Jul 2020 ongoing
Creators : Hervé Richard

Only one sample in a natural depression in the heart of the castle excavation.

Pollen analysis - Andelot-en-Montagne (F-39), Marais (KTH)

Collected date : 2016
Creators : Hervé Richard

Peat bog. 9 palynological samples. KTH testing (see : Sjörgen, P. 2007. Mires and Peat, International Mire Conservation Group and International Peat Society ; Gobet, 2014)

Pollen analysis - Auneau (F-28), 1996 : Le Parc du Château, forage A10

Collected date : from 1996 to 1997

Natural site: drilling. 71 palynological samples + 4 radiocarbon datings (one is wrong, too recent). Malacological studies by Nicole Limondin (1997).

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