Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds
A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Diversity-oriented Synthesis of Spiropyrrolo[1, 2-a]isoquinoline Derivatives via Diastereoselective and Regiodivergent Three-component 1,3-Dipolar Cycloaddition Reactions: In vitro and in vivo Evaluation of the Antidiabetic Activity of Rhodanine Analogues
An efficient diastereoselective route is developed to get access to novel spiropyrrolo[1,2-a]isoquinoline-oxindole skeletons by a one-potthree-component [3 + 2] cycloaddition reaction of (Z)-5-arylidene-1,3-thiazolidine-2,4-diones, isatin derivatives, and 1,2,3,4-tetrahydroisoquinoline (THIQ). ...
COMMON: COMplete view of the MONoceros OB1 molecular complex
The record presents the millimetre observations of the Monoceros OB 1 molecular cloud obtained with the TRAO-14m telescope (South Korea) in the frame of the large programme COMMON. The targeted lines are 12CO and 13CO (J=1-0) with angular resolution ~50 arcsec, spectral resolution 0.2 km/s, and ...
The Galactic cold cores molecular follow-up: the filament-core connection
This record presents observations conducted with the IRAM 30m telescope for the field G202+02, a filament part of the Monoceros OB 1 molecular complex. The observations are composed of on-the-fly maps of the rotational emissions of 12CO, 13CO, C18O and N2H+ (J=1-0), as well as CS (J=2-1). The raw ...
Galactic cold cores: IV. Source extraction maps
This record presents the maps published by the Galactic cold cores project in the paper IV (Montillaud et al. 2015) for the 116 fields observed with the Herschel space observatory. An excerpt of the maps can be found in appendix G of the paper. The full set of maps is available through the Muffins ...
