New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Diversity-oriented Synthesis of Spiropyrrolo[1, 2-a]isoquinoline Derivatives via Diastereoselective and Regiodivergent Three-component 1,3-Dipolar Cycloaddition Reactions: In vitro and in vivo Evaluation of the Antidiabetic Activity of Rhodanine Analogues
An efficient diastereoselective route is developed to get access to novel spiropyrrolo[1,2-a]isoquinoline-oxindole skeletons by a one-potthree-component [3 + 2] cycloaddition reaction of (Z)-5-arylidene-1,3-thiazolidine-2,4-diones, isatin derivatives, and 1,2,3,4-tetrahydroisoquinoline (THIQ). ...
Japanese disasters database
Based on the study of newspaper articles from the Japanese English-language newspaper ‘The Japan Times’, the database contains all the catastrophic events (tsunamis, earthquakes, typhoons, etc.) recorded since the creation of the newspaper in the 1860s. until the 1970s.
HISTORISK database
The HISTORISK database lists and describes hazards having caused disasters and consequently recorded in archives and historic document (maps, paintings, newspapers, etc.) occured in France (mainland and overseas territories) since the Middle Ages. From 2018, new data of the same type will concern ...
Access
Discipline
- Chemistry, organic
- Crystallography
- Materials science, characterization & testing
- Mathematical & computational biology
- History
- Microbiology
- Meteorology & atmospheric sciences
- Environmental sciences
- Anthropology
- Oceanography
- Asian studies
- Chemistry, physical
- Communication
- Geology
- Geosciences, multidisciplinary
- Linguistics
- Nuclear science & technology
Structure
Collection
- Histoire des catastrophes
- Bioorganic synthesis
- PollenChrono
- Données de thèse
- Single-crystal X-ray structures
- Organic synthesis
- Calculated spectroscopic databases
- Dynamique des orogènes anciennes
- Chimie des eaux-basse vallée de l'Ain
- Microma
- Gaia
- Données de thèse de Jonas Vanardois
- Faults and shear zones
- Complex directed networks
- Données de thèse de Thomas Leydier
- OMIV
- Données de thèse de Charles Henriot
- Phytomanagement-Chrono
- Données de thèse de Alexandre Lhosmot
- CNR Echinococcoses
- Star formation
- Équipe SHARPAC
- Inorganic synthesis
- DATA-PHM
- Road-side counts
- Hydrogène
- Neuro group @ FEMTO-ST
- Paleoparasitology
- TNOs
- Pile à combustible
- Bacilles à Gram négatif dans l'environnement
- Données de thèse de Paul Breugnot
- Elaboration des matériaux luminescents
- Lipid model membranes
- Données de thèse de Florian Scalvini
- Molecular dynamics
- Génomique bactérienne
- Aspergillus fumigatus
- AVKs
- Organometallic complexes with metal-metal bonds
- Piézométrie Chrono-Environnement