Elsevier : Elsevier

Structure's type : other
Country : Netherlands (NLD)
3 results

New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies

In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...

Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors

In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...

Clay mineralogical and geochemical expressions of the "Late Campanian Event" in the Aquitaine and Paris basins (France): Palaeoenvironmental implications

Collected date : from 15 Aug 2013 to 15 May 2014

Campanian sediments from two French sedimentary basins were studied, using clay mineralogy and stable isotope (δ13C and δ18O) geochemistry, in order to investigate the Late Campanian Event. The clay fraction of the Campanian sediments from the Tercis-les-Bains section (Aquitaine Basin) and from the ...

3 results


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Université de Bourgogne, Université de Franche-Comté, UTBM, AgroSup Dijon, ENSMM, BSB, Arts des Metiers