Main affiliation : Normandie Université - Université Le Havre
3-spiroindolizines containing an isoindole ring through intra-molecular arylation of spiro-N-acyliminium species
Disciplines : chemistry, organic biochemistry & molecular biology
Collected date : from Jan 2017 to Oct 2018
Creators : Anthony Pesquet Hamid Marzag Michael Knorr Carsten Strohmann ...
Based on N-acyliminium species, efficient approaches to spirocyclic systems connected by two different carbon centers to the isoindole ring have been developed. The imide reduction and the tandem oxidative cleavage of olefin/formyl-amide equilibration were at first selected as the key steps for ...