Bioorganic synthesis
Creation of collection : 30 Sep 2021
New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Diversity-oriented Synthesis of Spiropyrrolo[1, 2-a]isoquinoline Derivatives via Diastereoselective and Regiodivergent Three-component 1,3-Dipolar Cycloaddition Reactions: In vitro and in vivo Evaluation of the Antidiabetic Activity of Rhodanine Analogues
An efficient diastereoselective route is developed to get access to novel spiropyrrolo[1,2-a]isoquinoline-oxindole skeletons by a one-potthree-component [3 + 2] cycloaddition reaction of (Z)-5-arylidene-1,3-thiazolidine-2,4-diones, isatin derivatives, and 1,2,3,4-tetrahydroisoquinoline (THIQ). ...
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- Bioorganic synthesis
- PollenChrono
- Données de thèse
- Single-crystal X-ray structures
- Organic synthesis
- Calculated spectroscopic databases
- Dynamique des orogènes anciennes
- Chimie des eaux-basse vallée de l'Ain
- Gaia
- Données de thèse de Jonas Vanardois
- Complex directed networks
- Microma
- Faults and shear zones
- Données de thèse de Charles Henriot
- Phytomanagement-Chrono
- Données de thèse de Thomas Leydier
- Données de thèse de Alexandre Lhosmot
- CNR Echinococcoses
- Star formation
- Inorganic synthesis
- Road-side counts
- Aspergillus fumigatus
- Bacilles à Gram négatif dans l'environnement
- Elaboration des matériaux luminescents
- Histoire des catastrophes
- OMIV
- Paleoparasitology
- TNOs
- Piézométrie Chrono-Environnement
- Molecular dynamics
- Lipid model membranes
- Génomique bactérienne
- AVKs
- Organometallic complexes with metal-metal bonds
