New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Pollen analysis - Les Rousses (F-39), Les Rousses lake
Natural site: peat bog near the lake's outlet. 16 palynological samples. The selection was made in several drillings. Two pollen tests performed in 2021 towards the lake outlet.
Pollen analysis - Vaux-lès-Saint-Claude (F-39), Eau Morte
Pollen tests in the filling of a circular depression (ice rest, pockmark?) in the heart of a meander of the Bienne. Two samples: 162 and 200 cm deep.
Diversity-oriented Synthesis of Spiropyrrolo[1, 2-a]isoquinoline Derivatives via Diastereoselective and Regiodivergent Three-component 1,3-Dipolar Cycloaddition Reactions: In vitro and in vivo Evaluation of the Antidiabetic Activity of Rhodanine Analogues
An efficient diastereoselective route is developed to get access to novel spiropyrrolo[1,2-a]isoquinoline-oxindole skeletons by a one-potthree-component [3 + 2] cycloaddition reaction of (Z)-5-arylidene-1,3-thiazolidine-2,4-diones, isatin derivatives, and 1,2,3,4-tetrahydroisoquinoline (THIQ). ...
Pollen analysis - Le Miroir (F-71), La Tuilerie (La Peupleraie), A39-T1 and T2
Natural site over the alignment of the A39 motorway; drilling. Two series: T1 (18 poor samples) and T2 (88 palynological samples + 2 radiocarbon datings). Samples often difficult to read. Publication CRAS, 1996.
Pollen analysis - Auneau (F-28), L'Hermitage (detour road 18/116/19)
Natural site: drilling with motorised "russian" core. 120 palynological samples. + 6 radiocarbon datings. 2015 publication: only the "gallo-roman" part.
Pollen analysis - Villers-le-Lac (F-25), La Roche aux pêcheurs
Archaeological site: rock shelter. 10 palynological samples. Only one acceptable result. Archaeological excavation: Ch. Cupillard, SRA de Franche-Comté.
Pollen analysis - Fontenu (F-39), îlot David-1987, FG 30, 86 S-C, 86 G23
Archaeological site. Lake dwelling. 9 palynological samples (related to M. Magny PhD thesis, 1991).
Pollen analysis - Fontenu (F-39), Lac de Chalain, îlot David, A 33/34
Archaeological site. Lake dwelling. 11 palynological samples.
Pollen analysis - Héricourt (F-70), La Lizaine (chemin de l'usine)
Archaeological excavation of rural settlement. 7 palynological samples. Approximate geographical coordinates.
Pollen analysis - Grozon (F-39), L'étang (Marais)
Natural site: wooded swamp. 144 palynological samples with 2 radiocarbon datings. Sometimes quite poor. Further analyses were done in the village of Grozon around the salt springs by E. Gauthier (PhD, 2001).
Pollen analysis - Clairvaux-les-lacs (F-39), Station II
Archaeological site. Lake dwelling. 14 palynological samples + radiocarbon and dendrochronological datings.
Pollen analysis - Bonlieu (F-39), Le Lautrey (point 205)
Peat bog; 51 palynological samples. Other analyses on this site by Carole Bégeot and Pascale Ruffaldi (2006)
Pollen analysis - Le Locle (NE, CH), Col des Roches (Projet H20)
The archaeological surveys carried out on the Le Locle bypass road have made it possible to make several test borring in the upper part of the fill of the area located south of the city, between the city and the Col des Roches, in the Marais des Calame and Marais de la Molière. Two sections were ...
Pollen analysis - Fontenu (F-39), Domaine CID I et CID II
Two boreholes (CID I of 5.77 m and CID II of 7.63 m) were drilled off the Domaine de Chalain (east bank), 65-70 m from the shore. 57 pollen samples were taken from CID I and 21 from CID II + 5 radiocarbon dates.
Pollen analysis - La Châteleine (F-39), Au vieux château
Only one sample in a natural depression in the heart of the castle excavation.
Pollen analysis - Andelot-en-Montagne (F-39), Marais (KTH)
Peat bog. 9 palynological samples. KTH testing (see : Sjörgen, P. 2007. Mires and Peat, International Mire Conservation Group and International Peat Society ; Gobet, 2014)
Pollen analysis - Auneau (F-28), 1996 : Le Parc du Château, forage A10
Natural site: drilling. 71 palynological samples + 4 radiocarbon datings (one is wrong, too recent). Malacological studies by Nicole Limondin (1997).
Pollen analysis - Boécourt (Suisse, Jura), Les Pécats (Les Montoyes)
Natural site: section. 44 palynological samples. Sterile or unavailable samples.
Pollen analysis - Corsier (Suisse, Genève), Marina
Lacustrin archaeological site: sub-lake drilling. 25 palynological samples in the core C1
Pollen analysis - Boncourt (Suisse, Jura), Le Neu Bois
Natural site: geological section. 13 palynological samples. Almost all sterile.
Pollen analysis - Ponsonby (Chili, Provincia Ultima Esperenza, Patagonia Austral), Emperaire/Legoupil excavations (Riesco Island)
Sections in an archaeological site. 146 palynological samples + 7 radiocarbon datings. 3 series: pingüino, locus 1 (very poor) et locus 2.
Pollen analysis - Villers-le-Lac (F-25), Les Prés Mourey
Archaeological site: rock shelter. 8 palynological samples. 6 radiocarbon datings. Archeological dig: Ch. Cupillard, SRA de Franche-Comté.
Pollen analysis - Montlebon (F-25), Sur la Vigne 1 (Morteau A)
Natural site: wet meadow. 99 palynological samples + 4 radiocarbon datings. Drilling of 28.10 meters length.
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