New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
In a sustained search for novel and effective antihyperglycemics, a new series of fifteen isomeric oxazolone-fused dispiropyrrolothiazoles resulting from one-pot three component reaction between L-4-thiazolidine carboxylic acid, arylidene-oxazolones and isatin (or acenaphthenequinone) has been ...
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3′-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized ...
Diversity-oriented Synthesis of Spiropyrrolo[1, 2-a]isoquinoline Derivatives via Diastereoselective and Regiodivergent Three-component 1,3-Dipolar Cycloaddition Reactions: In vitro and in vivo Evaluation of the Antidiabetic Activity of Rhodanine Analogues
An efficient diastereoselective route is developed to get access to novel spiropyrrolo[1,2-a]isoquinoline-oxindole skeletons by a one-potthree-component [3 + 2] cycloaddition reaction of (Z)-5-arylidene-1,3-thiazolidine-2,4-diones, isatin derivatives, and 1,2,3,4-tetrahydroisoquinoline (THIQ). ...
CECURE-Contamination of the Environment and Circulation in Urban and Rural areas of Echinococcus multilocularis
A copro-sample collection was created for the CECURE project. The aim of this study was to assess the relative role of carnivore hosts (mainly fox, dog, cat) in the speading and circulation of the parasite Echinococcus multilocularis in the urban and rural environnement in order to assess the ...
Mass screening for Alveolar echinococcosis in south Gansu, China
Data related to human population screening and dog surveys carried out in 1996-97, 2005-6 and in 2014/15 in South Gansu, China
DNA Library - CNR Echinococcoses
DNA Library is a database associated to a web interface, created to improve the storage and the life of a biological sample collection, closely related to the research activities of the National Reference Center for Echinococcosis (CNR Echinococcoses, University Hospital of Besançon, France). A ...
EWET : EmsB Website for Echinococcus Typing
The EWET database (EWET-DB) contains genotyping data on the parasite Echinococcus multilocularis, obtained after the analysis of the microsatellite EmsB. A set of information is also avaible on the sampled parasite isolates (host, geographical position, sampling conditions, laboratory of reference, ...
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- Bioorganic synthesis
- CNR Echinococcoses
- PollenChrono
- Données de thèse
- Single-crystal X-ray structures
- Organic synthesis
- Calculated spectroscopic databases
- Dynamique des orogènes anciennes
- Chimie des eaux-basse vallée de l'Ain
- Gaia
- Données de thèse de Jonas Vanardois
- Complex directed networks
- Microma
- Faults and shear zones
- Phytomanagement-Chrono
- Données de thèse de Charles Henriot
- Données de thèse de Thomas Leydier
- Données de thèse de Alexandre Lhosmot
- Star formation
- Inorganic synthesis
- Road-side counts
- Paleoparasitology
- Bacilles à Gram négatif dans l'environnement
- Histoire des catastrophes
- TNOs
- OMIV
- Elaboration des matériaux luminescents
- Génomique bactérienne
- AVKs
- Aspergillus fumigatus
- Lipid model membranes
- Molecular dynamics
- Organometallic complexes with metal-metal bonds
- Piézométrie Chrono-Environnement